郁飞等 《Nature Plants》 2019

　　论文题目：Noncanonical ATG8–ABS3 interaction controls senescence in plants

　　论文作者: Min Jia, Xiayan Liu, Hui Xue, Yue Wu, Lin Shi, Rui Wang, Yu Chen, Ni Xu, Jun Zhao, Jingxia Shao, Yafei Qi, Lijun An, Jen Sheen & Fei Yu

　　论文摘要：Protein homeostasis is essential for cellular functions and longevity, and the loss of proteostasis is one of the hallmarks of senescence. Autophagy is an evolutionarily conserved cellular degradation pathway that is critical for the maintenance of proteostasis. Paradoxically, autophagy deficiency leads to accelerated protein loss by unknown mechanisms. We discover that the ABNORMAL SHOOT3 (ABS3) subfamily of multidrug and toxic compound extrusion transporters promote senescence under natural and carbon-deprivation conditions in Arabidopsis thaliana. The senescence-promoting ABS3 pathway functions in parallel with the longevity-promoting autophagy to balance plant senescence and survival. Surprisingly, ABS3 subfamily multidrug and toxic compound extrusion proteins interact with AUTOPHAGY-RELATED PROTEIN 8 (ATG8) at the late endosome to promote senescence and protein degradation without canonical cleavage and lipidation of ATG8. This non-autophagic ATG8–ABS3 interaction paradigm is probably conserved among dicots and monocots. Our findings uncover a previously unknown non-autophagic function of ATG8 and an unrecognized senescence regulatory pathway controlled by ATG8–ABS3-mediated proteostasis.

　　论文链接：https://www.nature.com/articles/s41477-018-0348-x